Are fetal bilirubin levels associated with the need for neonatal exchange transfusions in hemolytic disease of the fetus and newborn?

BACKGROUND Fetal bilirubin is routinely measured at our center when taking a pretransfusion blood sample intrauterine transfusions in hemolytic disease of the fetus and newborn. However, clinical value fetal assessment not well known, information rarely used. We speculated that there could be role for this measurement predicting need neonatal exchange transfusion. OBJECTIVE This study aimed to evaluate predictive severe STUDY DESIGN A total 186 infants with Rh alloantibody–mediated newborn treated one or more Leiden University Medical Center between January 2006 June 2020 were included observational study. Antenatal postnatal factors compared without transfusion treatments. The primary outcome was levels before last relation RESULTS In multivariate logistic regression analysis, level (odds ratio, 1.32; 95% confidence interval, 1.09–1.61 per 1 mg/dL) number 0.63; 0.44–0.91 transfusion) independently associated area under curve determined 0.71. Youden index calculated 0.43. corresponding 5 mg/dL had sensitivity 79% specificity 64%. CONCLUSION high likelihood